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Antihypertensive treatment significantly ( P 0.001) reduced clinic and ambulatory systolic and diastolic BP from baseline in both alcohol drinkers and non-drinkers at 4 and 8 weeks of follow-up

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Once released in the cytosol active p53 induces cellintrinsic apoptosis by activating a caspasedependent pathway likely involved in previously reported transcriptionindependent p53mediated apoptosis at the mitochondria Effectively, FOXO4-DRI is able to selectively penetrate the senescent cells without targeting healthy cells due to the use of D-amino acids instead of L-amino acids

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