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When You Might Need Higher B12 Doses While the standard RNI of 1.5 mcg per day suffices for most healthy adults, certain medical conditions, dietary patterns, and medications can substantially increase B12 requirements or impair absorption, necessitating higher therapeutic doses under medical supervision

Just as HOOH (hydrogen peroxide) is more oxidized than HOH (O in H 2 O 2 has an oxidation number of 1- while the O in H 2 O has an oxidation number of -2), RSSR is the oxidized form (S oxidation number -1), and RSH is the reduced form (S oxidation number -2) of thiols

Fu, C., Begum, K., Jordan, P

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