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It is imperative to research novel avenues targeting immune checkpoint receptor proteins because of the treatment resistance, poor response, or considerable increase in toxicity of antibody medicines targeting PD-1/PD-L1 or CTLA-4 that have previously been found [222, 223]

The additives in pigment and gasoline, effluents of storage battery industries, melting and manufacturing factories, activities related to metal plating, and vehicle wastes are the potential sources for adding Pb to soils and environments (Figure 2) [19]

Microneedling has been 5