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The EMPA-REG and CANVAS trials showed that the SGLT-2i empagliflozin and SGLT-1/2i canagliflozin reduced the risk of MACE in T2D patients with or at high risk of CVD by 14%, while the SGLT-2i dapagliflozin did not significantly reduce the risk of MACE, possibly due to the difference in population (approximately 60% with no established ASCVD) between previous trials and strict exclusion criteria

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Specifically, TNF- induces lactylation of sex-determining region Y (SRY)-related HMG-box gene 10 (Sox10) via PI3K/AKT signaling, driving VSMC transdifferentiation and pyroptosis