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J Sci Food Agric 76:257262 Garg SS, Gupta J, Sharma S, Sahu D (2020) An insight into the therapeutic applications of coumarin compounds and their mechanisms of action

Mutagenesis (2015) 30(3):42130

Commonly reported alterations include a reduction in butyrate-producing bacteria such as Faecalibacterium prausnitzii and Butyricicoccus , and an increase in taxa that can induce pro-inflammatory responses (like Akkermansia muciniphila , Prevotella spp

However, the convenience of a single morning dose means most researchers prefer once-daily administration, and the clinical data supporting split dosing specifically for AOD 9604 is limited