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Since oxidative stress is associated with vascular dysfunction, the application of antioxidants could protect the renal microcirculation by maintaining endothelial function and reducing vascular permeability, thereby helping to prevent some vascular complications related to kidney diseases

DOI: 10.1074/jbc.274.20.13908 56

The vitamin can be stored in the liver for a long time, so it may take a few years for a deficiency to develop ( Summary Vitamin B12 is a water-soluble vitamin that plays an important role in brain function and red blood cell production

This is precisely why Lyme disease can go from just a tick bite to a full neurological, cardiac, or musculoskeletal condition if left unaddressed