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Its an autoimmune disease in which the immune system produces antibodies that attack the thyroid, causing fibrosis or scarring of the thyroid tissue ( Hashimotos disease is associated with a variety of symptoms, including weight gain, fatigue, hair loss, anemia, constipation, cold intolerance, joint pain, dry skin, mood changes, difficulty concentrating, and more ( In addition to medication, diet and lifestyle modification can help reduce thyroid damage and improve symptoms and overall quality of life in people with Hashimotos

1.1 Glutathione peroxidase Glutathione peroxidase (GPx) an mammalian enzyme, contains selenocysteine residue in its active site, For the last four decades, an extensive research has been carried out on the mammalian antioxidant enzymes GPx [34]

Moreover, heavy metals can deplete glutathione, a master intracellular antioxidant, by binding to thiol groups or interfering with glutathione synthesis and recycling (Ercal et al., 2001

Common side effects include redness or swelling at the injection site, mild diarrhea, and a temporary feeling of lightheadedness