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Tyrosine hydroxylase is the critical enzyme in the synthesis of epinephrine, norepinephrine and dopamine, and tryptophan hydroxylase is the essential enzyme in the synthesis of serotonin

Shank2 knockout mice (e67 KO) exhibit decreased expression levels of Gabra2 and GABA receptor-mediated inhibitory signaling, which can be reversed by treatment with allosteric modulators of GABA-ARs (99, 100)

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