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Human safety data is limited, so its full risk profile is not established

Depression, memory loss, and behavioral changes B12 Deficiency Treatments You may require shots of B12 at first

Neurological symptoms often develop gradually and may include: Paraesthesia : tingling or 'pins and needles' sensations, typically starting in the feet and hands Numbness : reduced sensation in the extremities, which may affect balance and coordination Burning pain : particularly in the feet, often worse at night Weakness : muscle weakness and difficulty walking Balance problems : unsteady gait and increased fall risk due to proprioceptive impairment Cognitive changes : memory problems, confusion, difficulty concentrating, and mood disturbances Haematological signs may accompany neurological symptoms and include fatigue, weakness, pallor, and shortness of breath due to megaloblastic anaemia

Some compounded tirzepatide formulations include B12 (methylcobalamin), and researchers report improved energy levels with this addition