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All authors interpreted the data, reviewed the manuscript, and approved the final version

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Data from the Health Professionals Follow-up Study and the Nurses Health Study assessed a low-risk lifestyle defined as not smoking, BMI less than 25 kg/m 2 , 30 minutes or more per day of moderate activity, modest alcohol consumption (men 5 g/d to 30 g/d, women 5 g/d to 15 g/d), and healthy diet

Since 2013, on 1 March and 1 September of each year, the excise has been adjusted by an indexation factor determined by changes to Average Weekly Ordinary Times Earnings (AWOTE) over the previous six months