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While DHAR1 has been localized to the peroxisomes, DHAR2 is cytosolic and DHAR3 encodes a dual-addressed chloroplast/mitochondrial enzyme (Figure 2)

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9799 In one study, the activation of genes associated with oxidative damage, including NQO1 and HMOX1, due to vaped VEA was larger than from duroquinone alone, 100 indicating that duroquinone may not be the only contributor to the adverse effects of VEA