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Studies found that fat mass reduction occurred without corresponding losses in lean tissue, indicating a muscle-sparing effect

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

Bibcode:1999JAFC...47.4736W

Additionally, B vitamins play a vital role in maintaining the health of the nervous system by contributing to the functions of both the central and peripheral nervous systems