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In addition, there is no adjustment for the effects that geographic reclassification, the proposed continuation of the lowest quartile hospital wage index adjustment, or the 5-percent cap on wage index decreases policy described previously have on the other payment parameters, such as the payments for DSH or IME

This has not been demonstrated in animal studies, but the mechanism warrants caution

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The clinical trial measured results at 24 and 48 weeks, not during individual dose steps, so specific per-step weight loss data is limited