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Causes of CD, include Alzheimers disease, degenerative diseases, vascular dementia, certain types of drug abuse, depression, anxiety, disturbed sleep, hormones, metabolic disorders, diabetes mellitus, alcohol abuse, Lyme disease, hippocampal sclerosis, subdual and epidural hematomas, vitamin B12 deficiency, seizures, HIV-associated neurocognitive disorder, and Hashimotos encephalopathy

In addition, deoxy-arbutin is a dose-dependent tyrosine hydroxylase inhibitor which can further inhibit the melanogenesis process

Results: Median age was 73 (IQR 62-81), 41% were female, 36% had a vessel occlusion and 76% presented with NIHSS 0-5