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Inside the cell, metal reductase six-transmembrane epithelial antigen of prostate 3 reduces trivalent iron ions to Fe 2+ , which are then released from the lysosome into the cytoplasm via solute carrier family 11 member 2 for participation in various subsequent physiological and biochemical processes [37, 38]

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each discovered a new tear fluid biomarker for AD, reporting elongation initiation factor 4E (eIF4E) 18 and adenylyl cyclase-associated protein 1 (CAP1) 19 , respectively