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it is a direct indicator of declining physical function that requires a targeted response

Most common is the use of 2-deoxy-2-(18F) fluoro-D-glucose positron emission tomography (PET), which measures energy demand by trapping a non-metabolizable glucose analog that carries a PET label

Connor et al ., 2004), these findings may seem surprising on the basis of classical receptor theory because for many GPCRs, there is a good correlation between agonist efficacy and the ability to induce receptor desensitization (Clark et al ., 1999)

However, over time, the effect on appetite decreased even though the weight loss continued