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Secondhand smoke is the combination of smoke that comes from the burning end of other people's cigarettes and the smoke out of the smokers mouth

COX2 can increase hepatic inflammation and promote collagen and TGF-1 expression of hepatic stellate cells 62 , and also can prevent abnormal differentiation of HBV-infected hepatocyte apoptosis by COX2/Wnt/catenin pathway 63

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Feng Z, Hu W, Hu Y, Tang M (2006) Acrolein is a major cigarette-related lung cancer agent: preferential binding at P53 mutational hotspots and inhibition of DNA repair