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Changes in lysine methylation contribute to the cytotoxicity of curcumin in colon cancer cells

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

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This cascading event is exacerbated by aging with a declining proteostasis, thereby reducing the cells ability to protect its more vulnerable proteins from coaggregation, eventually resulting in the collapse of essential cellular functions