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In most cases, these symptoms are mild to moderate and improve over time, but they can be severe enough for some patients to discontinue treatment (semaglutide STEP 1 trial results)

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Doses above recommended levels have not been shown to cause harm

According to the Office of Dietary Supplements, the following people are most at risk for thiamine deficiency: Older adults Those dependent on alcohol People with HIV/AIDS People with diabetes Those who have had bariatric surgery Mount Sinai: "Thiamin" National Institutes of Health Office of Dietary Supplements: "Thiamin" Mayo Clinic Laboratories: "Thiamine (Vitamin B1), Whole Blood" America's Poison Centers: "Get online poison help now" PubChem: "Thiamine Hydrochloride - Safety and Hazards" BMJ Case Reports: "Anaphylactic Shock and Cardiac Arrest Caused by Thiamine Infusion" MedlinePlus: Thiamine (Vitamin B1) Lynn Grieger, RDN, CDCES Medical Reviewer Lynn Grieger is a registered dietitian-nutritionist, certified diabetes care and education specialist, certified personal trainer, and certified health and wellness coach