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Moreover, iron-induced oxidative damage compromises the BBB, allowing harmful substances to infiltrate the brain and intensify neuroinflammation, creating a vicious cycle of neuronal dysfunction and degeneration [85,101,102]

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It can inhibit Th1-type and promote Th2-type immune responses, which are responsible for regulating diverse homeostatic and inflammatory processes (Shibata et al., 2005)

The objectives of this study were to determine whether exogenous application of 5-oxp could promote heat tolerance in cool-season perennial grass species and identify the major metabolic pathways that could be activated or responsive to 5-oxp for enhancing heat tolerance