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Funding The present study was supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project (2024ZD0531400,2023ZD0507302), the National Key R&D Program of China (2022YFA0806101), the National Natural Science Foundation of China (81920108009, 82130023, 82570968, 82200923), the Research and Innovative Team Project for Scientific Breakthroughs at Shanxi Bethune Hospital (2024AOXIANG03), the Continuous Funding Program for High-Level Research Achievements at Shanxi Bethune Hospital (2024GSPYJ10 and 2024GSPYJ13) and the IGP Funding from QBRI, Hamad Bin Khalifa University