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- [Stability of Reconstituted Peptide Formulations Under Refrigerated Storage]( *International Journal of Pharmaceutical Compounding*, 2023

The comparatively high values for Vss of free cobalamins-(III) are due to the high protein binding of hydroxocobalamin as it reacts in the blood with plasma constituents to form cobalamins-(III) complexes and the rapid distribution of free cobalamins-(III) into tissues

In fact, its been found that B12 supplements taken orally are just as effective as intramuscular shots in overcoming states of deficiency when you take up to 1,000 micrograms a day

Image 1: Cellular metabolism of various forms of vitamin B12 Image: Simplified depiction of the metabolism of various forms of vitamin B12 supplements in the cytosol