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Summary: Vitamin B12 supplements can occasionally cause mild stomach side effects including nausea, diarrhoea, abdominal cramping, and indigestion, though these are generally uncommon and temporary

Cory, A.W

More recently, a randomized, double-blind, placebo-controlled trial in 215 men, aged 35 to 55 years, examined the effects of supplemental B vitamins (at 3 to 13 times the current RDA, except for folic acid which was included at a dose equivalent to the RDA), vitamin C (500 mg/day), and the minerals, zinc (10 mg/day), calcium (100 mg/day), and magnesium (100 mg/day) on mood and perceived stress (134)

More information can be found on the DSRIP webpage here