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Specifically, fluconazole treatment led to a 20% decrease in GSH levels in Candida albicans ATCC 10231, Candida albicans which are fluconazole-sensitive strains, Candida tropicalis , and Candida metapsilosis

Research models show it delivers Cu ions to copper-dependent enzymes (lysyl oxidase chief among them) that crosslink collagen and elastin fibers, producing denser, more resilient extracellular matrix

Animals receiving BPC-157 showed significantly better collagen fiber organization, higher biomechanical tendon strength, and faster attachment reintegration compared to controls

The systemic copper load from topical application is minimal, so there's generally no concern about combining routes