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2017;96(47):e8562

Introduction General anesthesia (GA) is a common clinical intervention, with nearly 230 million surgical procedures taking place under GA across the world every year ( Although the exact mechanisms by which GA agents work are yet to be fully elucidated, they are widely considered to suppress neuronal firing ( Beyond altering neuronal transcription, neuronal activity also has consequences on gene expression in nearby non-neuronal cells

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In addition, EDV regulates the hypothalamicpituitaryadrenal (HPA) axis via downregulation of FK506 binding protein 5 (FKBP5), a protein involved in glucocorticoid receptor (GR) trafficking to the nucleus, which may contribute to normalization of stress-induced abnormalities in the HPA axis (Herbet et al., 2019)