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There was more stable production over time in these systems compared to the non-selected controls, although the production under selection did not surpass the original control levels

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WADA Prohibition The World Anti-Doping Agency classifies both peptides as prohibited substances for competitive athletes: Section S2 classification Peptide Hormones, Growth Factors, and Related Substances Prohibited at all times (both in-competition and out-of-competition) No Therapeutic Use Exemptions available not recognized as legitimate medical treatments Performance-enhancing potential acknowledged due to growth hormone secretagogue effects Detection methods under development for anti-doping testing programs WADAs position reflects that these peptides possess clear performance-enhancing properties and lack approved therapeutic applications that would justify medical use exemptions

Apart from 461 amino acid residues and the prosthetic group FAD, the model contains 524 solvent molecules, about 118 of which can be considered an integral part of the enzyme