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Non- compartmental pharmacokinetic parameters were calculated from serum drug concentration- time profiles by use of WinNonlin software (Pharsight, Mountain View, CA, USA)

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H-Bond Interaction: DMF accepts, Water donates The carbonyl oxygen of DMF (C=O) is a strong H-bond acceptor

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Mizuno K., Kume T., Muto C., Takada-Takatori Y., Izumi Y., Sugimoto H., Akaike A