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The IKK complex is made up of the catalytic subunits IKK and IKK as well as the regulatory component IKK (NEMO) (122)

Wild type SOD1 can be misfolded by the aberrant translation, post-translational modification or oxidative modifications, due to the pathological conditions of the CNS environment, and produce toxic insoluble aggregates, as mutated SOD1 (Bosco et al., 2010

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