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In the first step, GSH forms an adduct with methylglyoxal (synonyms, 2-oxopropanal and pyruvaldehyde), a potentially toxic byproduct of glycolysis (Chakraborty et al., 2014, Allaman et al., 2015), yielding the glutathione S -conjugate S -d-lactoylglutathione in a reaction catalyzed by glyoxalase I

Several points of synergy amplify the combined effect

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Nag SA, Qin JJ, Wang W, Wang MH, Wang H, Zhang R