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This particular form represents the most reduced and chemically reactive state of cobalamin, rendering it highly receptive to binding a methyl group from a form of vitamin B9 called 5-methyltetrahydrofolate, the product of methylenetetrahydrofolate reductase (MTHFR), to generate methylcobalamin (MeCbl)

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Key Findings from Preclinical Research Insights from Animal Studies While we always look to human trials for definitive answers, preclinical research offers a powerful window into how a compound works