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Importantly, NNMT is a dominant component of the gene expression signature for sarcopenia, overexpression of which could lead to significantly reduced levels of NAD+ and associated declines in muscle mass, strength, and function that accompany aging

PPAR, a nuclear receptor transcription factor, enhances cellular antioxidant capacity by regulating antioxidant enzyme expression and reducing ROS levels (138)

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Experimental studies suggest it may also have mild anticoagulant effects by inhibiting clotting factors