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The peptide is unique among neuropeptides in several respects: it does not conform to typical neuropeptide structural motifs, its distribution in the brain and periphery differs from classical sleep-promoting substances, and it appears to exert effects through multiple pathways rather than through a single characterized receptor system

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Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222