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Although pharmaceutical medicine has historically looked to plants as sources of the starting materials for drug development, the ultimate therapeutic molecule is typically quite different from the original plant-derived source

doi: 10.1186/s40580-019-0193-2

This occurs when receptors receptors for the excitatory neurotransmitter such as the NMDA and AMPA receptors are overactivated. Wikipedia Interestingly, given the low blood flow problems in chronic fatigue syndrome, central nervous system ischemia (low blood flows) increases glutamate levels and contributes to cellular death

Peptides naturally occur in tissues like the gut , brain , muscles , and immune system , but can also be synthesized and modified for therapeutic or performance-enhancing purposes