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Italian guidelines for the diagnosis and management of gastro-esophageal reflux disease: joint consensus from the italian societies of: gastroenterology and endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), AND General Medicine (SIMG)

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Concurrently, iron-mediated radical reactions further amplify oxidative stress, thereby lowering the cellular threshold for ferroptosis-related damage under conditions of sustained metabolic and redox perturbation [288,289,290]