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Together, our data suggest that there is significant cross talk between the injured kidney and the liver during ischemic AKI

The latter shows the complexity of this topic as high throughput genetic screening was necessary, which requires high effort in terms of cost and interpretation and is therefore not suited for daily clinical practice ( To date there is no general recommendation regarding pre-emptive genotyping, even though doubling the first Tac dose after solid organ transplantation is recommend in known CYP3A5 expressors