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Studies show that quercetin upregulates the expression of the ABCG2 transporter (which helps remove uric acid) while blocking URAT1 and GLUT9 (which keep uric acid in your blood) [5]

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Hence, the authors are concluding that it's worth it to conduct trials in humans (Valizadeh et al., 2021)

Genetic advances and functional characterizations of the pathophysiological alterations in receptor channel trafficking and function are changing our understanding of IGEs showed clear that genetic mutation of transmembrane ion channels is the underlying cause of many forms of human IGEs (ONeill et al