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A.LaunayP.SchmitzC.et al
-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia
After oral administration, statins enter the intestine via the upper gastrointestinal tract and affect the abundance of gut microbiota, which in turn modulates microbiota-derived metabolites such as SCFAs, secondary bile acids (SBAs), TMA, and LPS
386 Subsequently, Ma verified that the inhibition of DNA-PKcs effectively reduced the expression of inflammatory factor INF2 and excessive mitochondrial fission, following with alleviated cardiomyocyte dysfunction
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