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As previously described, perinatal dietary transitions often induce ruminal dysbiosis, which compromises glucogenic precursor supply and promotes extensive fat mobilization, thereby leading to excessive ketone body production in the liver

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When the methylation cycle stalls due to a lack of 5-MTHF, a toxic amino acid called homocysteine begins to accumulate in the bloodstream

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Post-operatively the animals were housed individually in an American Accreditation for Laboratory Animal Care-approved vivarium maintained at 22 1 C on a 12-h alternating light/dark cycle initiated at 06:00 h

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