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53 GLP-1 RA oral agents in development for obesity treatment Semaglutide In a phase 3, randomized, double-blind trial, once-daily 50 mg of oral semaglutide an adjunct to diet and physical activity in adults with pre-obesity or obesity (without diabetes) for 68 weeks induced significant weight reduction compared to placebo (15.1% vs

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However, overall body weight was still reduced by 5.0% to 9.8% at the end of week 32 in the groups administered cagrilintide and by 7.2% at the end of week 32 in the group administered liraglutide [1]