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Abstract Smoking-related lung abnormalities are now an increasing public health concern

The clinical significance of vascular endothelial function has become clear in many aspects such as understanding the etiology, pathogenesis, involvement in the development of atherosclerosis, therapeutic targets, and prognostic factors

Recall Brown and Williamsons 1980s demonstration that Merit cigarettes had only half the total nicotine of Marlboro cigarettes while still delivering the same amount of free nicotine, thanks to only a 0.5 increase in pH