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66 On the contrary, BCAT 1 has stronger reducing and antioxidant properties

MTX also decreases endogenous antioxidant activity by inhibiting the glucose-6-phosphate dehydrogenase enzyme, so it decreases nicotinamide adenine dinucleotide phosphate (NADPH) level, which is necessary for the formation of the reduced form of glutathione (GSH), which is responsible for scavenging ROS like hydrogen peroxide molecules.[ , , ] In addition, it is well known that ROS formation will induce autophagic cell death and apoptosis.[ , ] Pomegranate (Punica granatum, Punicaceae) is a fruit widely cultivated in different parts of the world

It was thought that morphine behaved in this fashion because in many tissues and cell systems, it is a partial agonist at the MOPr (Zhang et al ., 1996

Masaki, et al