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Gradually increase the dosage to the desired level to minimize potential side effects such as headaches or gastrointestinal discomfort

The effects of genetic polymorphisms on the rates of drug metabolism are well known, but how these polymorphisms influence the susceptibility to drug-drug interactions is less clear, in particular considering warfarin-drug interactions, whether reduced function proteins (e.g., CYP2C9*3 ) are inhibited to the same extent in vivo as wild-type proteins (e.g., CYP2C9*1 )

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STAT3 signaling not only inhibit inflammatory responses but also provokes cellular senescence via the STAT3/SOCS/p53 pathway [10]