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Although it has protective antioxidant functions, its surge may also alter copper kinetics, potentially increasing the delivery of redox-active copper to tissues or disrupting its cellular utilization, thereby paradoxically exacerbating copper-mediated toxicity in cardiomyocytes [177]

Crevensten G, Walsh AJ, Ananthakrishnan D, Page P, Wahba GM, Lotz JC, Berven S: Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs

The TG accumulation in adipocytes depends mainly on the availability of plasma VLDL and genetically fat chickens presented high levels of VLDL

Effect of drugs that affect P450 activity The toxicity of acetaminophen is due to the action of several P-450 cytochromes (CYPs) that catalyze the synthesis of NAPQI from APAP