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Jarrar YB, Lee SJ

(1) uninfected macrophages express anti-inflammatory responses, including polarization of CD206 + M2 macrophages and increased expression of IL10, whereas (2) infected macrophages show inflammatory responses, including differentiation to M1 macrophages and increased expression of iNOS, TNF-, and IL6

However, another study failed to demonstrate the association, because of no difference in bacterial dominance from induced sputum in asthma patients between ex-smokers and non-smokers, this lack of difference may be explained by the small sample size and different samples in that study [97]

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