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A landmark study published in the American Journal of Physiology found that AOD 9064 demonstrated fat-reducing effects without the hyperglycaemic properties of unmodified HGH

Moreover, this effect is combined to a downregulation of the expression of senescence-associated cytokines in the second model and an improvement of mice physical condition in the third model, respectively 37

As a consequence, a loss of lipoic acid-dependent enzymatic activity caused by defects in endogenous lipoic acid synthesis (see Deficiency) cannot be rescued by the provision of exogenous lipoic acid (5)

It also activates other crucial enzymes, including extracellular SOD3, ferroxidase ceruloplasmin (CP) (vital for iron metabolism), and lysyl oxidase (LOX) [24]