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At the same time, it also possesses a highly flexible high-affinity iron transport system that can switch different uptake strategies by sensing changes in host microenvironment iron concentrations, adapting to both commensal and pathogenic states (Mamouei et al., 2017)

Conversely, a cohort study using standard dietetic advice to produce intentional weight loss in older adults with T2D demonstrated that every 1 kg of weight loss was an associated 34 months survival prolongation [64], and a meta-analysis of RCTs assessing the impact of intentional weight loss on mortality found a 15%, although the mean age of participants was 52 years [65]

2024 doi: 10.1101/2024.06.18.24309100

Upstream molecular targets, such as Nrf2, Sirt3, and PPAR-, are responsible for the curcumin-enhanced GSH system [184,185,186]