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acknowledges funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, SCHU 2494/3-1, SCHU 2494/7-1, SCHU 2494/10-1, SCHU 2494/11-1, SFB 829, KFO 286, KFO 329, GRK 2407) and the Deutsche Krebshilfe (70112899)

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