If you have a certain mutation on the MTHFR gene that produces this enzyme or if you have an overload of toxins in your body not allowing the methylation cycle to startyou can get in a sticky situation of your bodys natural functions being disrupted
63 Moreover, mucosal inflammation in claudin-7 KO mice appears to be a product of epithelial cell instability and not necessarily the result of barrier deregulation, given that no apparent gut leakiness was documented at early time points in these mice
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Journal of Cerebral Blood Flow and Metabolism 30(5):10081016
