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Clinical Insight Social isolation is a potent, biologically mediated driver of negative affect and aggressionpartly via tachykinin 2 signalingwith preclinical evidence that NK3 receptor antagonism can normalize isolation-induced aggression, fear, and anxiety without sedation

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Concentrations of GSH and GSSG were calculated from the IS calibration by interpolating the constructed linear-regression curves, with the analyte to IS peak ratios measured from sample solutions

The fact that nesfatin-1 co-localizes with neuroendocrine hormones, such as GHRH or somatostatin, may support this possibility