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Diindolylmethane and Its Halogenated Derivatives Induce Protective Autophagy in Human Prostate Cancer Cells via Induction of the Oncogenic Protein AEG-1 and Activation of AMP-Activated Protein Kinase (AMPK). Cellular Signalling, vol

Nature 368 , 502 (1994)

When injected into or near specific muscles, research shows preferential growth and development of those muscles, limited systemic circulation due to rapid degradation, reduced whole-body effects compared to systemic analogs, and potential for site-specific muscle enhancement

That factor turned out to be a three-amino-acid peptide Gly-His-Lys and its biology, in the body, runs through its capacity to bind a single Cu(II) ion at the histidine imidazole, the deprotonated glycyl-histidyl peptide-bond nitrogen, and the alpha-amino group of glycine